General & history
- Medical and family history
- Physical examination
- Vital signs, height, and weight
- Diagnosis, genotype, and enzyme activity
- Treatment status and concomitant medications
- Quality-of-life measures
Educational summary only. Refer to the current authorized protocol and treating physician for actual timing and requirements.
Renal
- Serum creatinine and related laboratory measures
- Estimated glomerular filtration rate
- Urine protein or albumin assessment
- Dialysis or transplant history
- Event-based follow-up
Educational summary only. Refer to the current authorized protocol and treating physician for actual timing and requirements.
Cardiac
- Electrocardiogram
- Echocardiography
- Cardiac imaging when clinically indicated
- Rhythm and event history
- Blood pressure and cardiovascular risk assessment
Educational summary only. Refer to the current authorized protocol and treating physician for actual timing and requirements.
Neurologic & cerebrovascular
- Pain and neuropathic symptoms
- Sweating and temperature intolerance
- Transient ischemic attack and stroke history
- Neurologic evaluation when indicated
- Hearing and other relevant symptoms
Educational summary only. Refer to the current authorized protocol and treating physician for actual timing and requirements.
Other domains
- Gastrointestinal symptoms
- Skin findings
- Ophthalmologic findings
- Respiratory assessment
- Patient-reported outcomes and fatigue
Educational summary only. Refer to the current authorized protocol and treating physician for actual timing and requirements.
Individualized care comes first.
Historical materials stated that physicians determine the actual frequency of assessments according to individualized medical needs and routine follow-up.